CBD, THC and Your Health
THC/CBD and other cannabinoids in the cannabis plant have a multitude and varied effects on a number of ailments that plaque the human condition.
Cannabis is known to help anxiety, depression, pain, sleeplessness, nausea, epilepsy and even cancer.
Cannabis is unique, however, in that it effects different people in different ways so what works for one person may or may not work for the next.
It appears people may need to try different types to in seeking the cannabis that works best for them and their specific problem.
How CBD kills cancer cells
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
So, a program of, say 2-4 months may be good for starters but be careful to drink a lot of water as CBD/THC dehydrates you and can cause liver damage if overused.
Side effects of CBD
If a person stops taking CBD, they may experience insomnia.
The cannabinoid receptors in the brain do not act the same way as many other drug receptors. For this reason, there may be a lower risk of side effects.
Unlike traditional medications for pain management, there are no apparent lethal doses of CBD. This is because the drug does not affect the central nervous system in the way that opiates do. However, the cannabinoid receptors are widespread in the body, so CBD affects not only the brain, but also many other organs and tissues.
Small-scale studies have found that people generally tolerate CBD well, but some individuals may experience mild side effects.
CBD can also interact with a range of medications and cause liver damage. These medications include: antibiotics, antidepressants, anti-anxiety medications, anti-seizure medications, blood thinners, chemotherapy drugs, muscle relaxers, sedatives, or sleep aids
People should exercise caution when taking CBD alongside prescription medications that warn about possible interactions with grapefruit.
Increased liver toxicity is a possible side effect of CBD. In one 2019 study in the journal Molecules, researchers administered varying doses of CBD to mice. The mice that received higher doses experienced liver damage within 1 day.
However, the manufacturers of Epidiolex also warn of its potential to cause liver problems in the product's safety information.
US Government data and reports on Cancer and CBD/THC